Spector A A, Ameen M, Schmiedt R A
Department of Biomedical Engineering and Center for Computational Medicine and Biology, Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA.
Biomech Model Mechanobiol. 2002 Oct;1(2):123-35. doi: 10.1007/s10237-002-0012-1.
We analyze the deformation of the outer hair cell and its production of active force under physiological conditions. The active force has two components. One results from the strain caused by loading in the organ of Corti in the cochlea and depends on the level of the acoustic signal; the other is related to the intrinsic active properties of the cell membrane. We demonstrate our approach by considering, as a basic model of an outer hair cell in the organ of Corti, a cylindrical shell that is filled with an incompressible fluid and located between two planes that move relative to each other. These planes represent the basilar membrane and tectorial membrane complexes. We show that the deformed state of the cell has a 3-D nature, including bending and twisting components. This is different from the experimental conditions in which the active force is usually measured. We estimate the active force as a function of the relative position of the planes, angle of the cell's inclination, and the cell length.
我们分析了外毛细胞在生理条件下的变形及其产生的主动力。主动力有两个组成部分。一个是由耳蜗柯蒂氏器中的负载引起的应变产生的，并且取决于声信号的水平；另一个与细胞膜的内在活性特性有关。我们通过考虑一个充满不可压缩流体且位于两个相对运动平面之间的圆柱壳，作为柯蒂氏器中外毛细胞的基本模型，来展示我们的方法。这两个平面代表基底膜和盖膜复合体。我们表明，细胞的变形状态具有三维性质，包括弯曲和扭转分量。这与通常测量主动力的实验条件不同。我们估计主动力是平面相对位置、细胞倾斜角度和细胞长度的函数。
