使用tat肽及其衍生物进行细胞内货物递送。

Intracellular cargo delivery using tat peptide and derivatives.

作者信息

Zhao Ming, Weissleder Ralph

机构信息

Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Rm 5404, Bldg 149, 13th St. Charlestown, Massachusetts 02129, USA.

出版信息

Med Res Rev. 2004 Jan;24(1):1-12. doi: 10.1002/med.10056.

DOI:10.1002/med.10056

PMID:14595670

Abstract

Efficient delivery of therapeutic and diagnostic agents across the plasma membrane is crucial in developing novel therapies. Membrane permeating peptides, in particular HIV-1 tat peptide and its derivatives, have enabled the intracellular delivery of cargos of various sizes and physicochemical properties. This review summarizes the current knowledge of tat-derived cell permeating peptides in the transduction of exogenous molecules/complexes.

摘要

在开发新型疗法中，治疗和诊断药物有效穿过质膜至关重要。膜渗透肽，特别是HIV-1反式激活因子（tat）肽及其衍生物，能够实现各种大小和物理化学性质的货物的细胞内递送。本综述总结了tat衍生的细胞穿透肽在外源分子/复合物转导方面的现有知识。