使用细胞穿透肽的细胞内转导

Intracellular transduction using cell-penetrating peptides.

作者信息

Sawant Rupa, Torchilin Vladimir

机构信息

Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, MA 02115, USA.

出版信息

Mol Biosyst. 2010 Apr;6(4):628-40. doi: 10.1039/b916297f. Epub 2009 Dec 21.

DOI:10.1039/b916297f

PMID:20237640

Abstract

Cell penetrating peptides (CPPs), TATp, in particular, has been used widely for intracellular delivery of various agents ranging from small molecules to proteins, peptides, range of pharmaceutical nanocarriers and imaging agents. This review highlights the mechanisms of CPP-mediated delivery and summarizes numerous examples illustrating the potential of CPPs in the fields of biology and medicine.

摘要

细胞穿透肽（CPPs），尤其是TATp，已被广泛用于将各种物质进行细胞内递送，这些物质范围从小分子到蛋白质、肽、一系列药物纳米载体和成像剂。本综述重点介绍了CPP介导递送的机制，并总结了大量实例，阐明了CPPs在生物学和医学领域的潜力。