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[良性前列腺增生的药物治疗]

[Pharmacologic treatment of benign prostatic hyperplasia].

作者信息

Romics Imre

机构信息

Semmelweis Egyetem, Altalános Orvostudományi Kar, Urológiai Klinika, Budapest.

出版信息

Orv Hetil. 2003 Sep 14;144(37):1809-14.

Abstract

Medical treatment for benign prostatic hyperplasia is reviewed by the author. Experiences with herbal extracts have been known for more than 2 decades. Treating benign prostatic hyperplasia with these extracts are recommended in initial phase. Effectiveness of these drugs are approved by some placebo controlled double blind studies. However effectiveness of these are not as good as medical drugs'. It is well known that they have no side effects and are cheaper than medicines. Prostate volume is decreased and mechanical component of dysuria is improved by treating for long time (months, years) with 5 alfa reductase finasterid which contain hormone. This drug is indicated when volume of the prostate is over 40 g. Dynamical component of benign prostatic hyperplasia is treated with a receptor blockers which act on the bladder neck. These medicines effect earlier and are recommended for all benign prostatic hyperplasia patients independently of prostate volume. These might have some side effect like hypotension.

摘要

作者对良性前列腺增生的医学治疗进行了综述。草药提取物的应用经验已有二十多年。在初始阶段推荐使用这些提取物治疗良性前列腺增生。一些安慰剂对照双盲研究证实了这些药物的有效性。然而,它们的效果不如药物好。众所周知,它们没有副作用且比药物便宜。使用含激素的5α还原酶非那雄胺长时间(数月、数年)治疗可使前列腺体积减小,并改善排尿困难的机械性因素。当前列腺体积超过40克时可使用此药。良性前列腺增生的动力性因素用作用于膀胱颈的受体阻滞剂治疗。这些药物起效更快,推荐用于所有良性前列腺增生患者,无论前列腺体积大小。它们可能会有一些副作用,如低血压。

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