Reghunandanan R, Reghunandanan V, Marya R K
Department of Physiology, Medical College, Rohtak, India.
Indian J Exp Biol. 1992 Apr;30(4):347-9.
All the parameters of renal function (inulin clearance, para amino hippuric acid clearance and urine flow) which were depressed during experimentally induced hemorrhagic shock in dogs improved significantly in addition to improvement in mean arterial pressure (MAP) after bolus administration (iv) of 1 or 2 mg/kg naloxone. A smaller dose (0.5 mg/kg) of naloxone, however, did not improve the renal function. Even renal arterial injection of the same dose of naloxone showed no improvement in the renal function. In both these cases the improvement in the MAP was significantly less as compared to other groups of animals which received 1 or 2 mg/kg naloxone. It may be concluded that (a) naloxone at doses of 1 or 2 mg/kg improved the renal function by improving MAP and (b) naloxone has no direct action on renal vasculature.
在实验性诱导犬失血性休克期间降低的所有肾功能参数（菊粉清除率、对氨基马尿酸清除率和尿流率），在静脉推注1或2 mg/kg纳洛酮后，除平均动脉压（MAP）改善外，也显著改善。然而，较小剂量（0.5 mg/kg）的纳洛酮并未改善肾功能。即使经肾动脉注射相同剂量的纳洛酮，肾功能也未改善。在这两种情况下，与接受1或2 mg/kg纳洛酮的其他动物组相比，MAP的改善明显较小。可以得出结论：（a）1或2 mg/kg剂量的纳洛酮通过改善MAP改善了肾功能；（b）纳洛酮对肾血管系统无直接作用。
