Srivastava S, Seth P K, Srivastava S P
Reproductive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
Indian J Exp Biol. 1992 May;30(5):399-401.
Effect of styrene (100 or 200 mg/kg body wt/day) for 60 days was observed on testicular enzymes of postnatally maturing rats. A significant decrease in epididymal spermatozoa count was observed only at 200 mg/kg body weight dose. Activities of testicular sorbitol dehydrogenase and acid phosphatase decreased while activities of lactate dehydrogenase, beta-glucuronidase, glucose-6-phosphate dehydrogenase, and gamma-glutamyl transpeptidase significantly increased only in animals exposed to styrene at a dose of 200 mg/kg body weight. The results suggest that exposure to high dose of styrene during developmental period alters the activities of enzymes associated with specific cell type of testis.
观察了苯乙烯（100或200毫克/千克体重/天）对出生后成熟大鼠睾丸酶的影响，持续60天。仅在200毫克/千克体重剂量下观察到附睾精子计数显著下降。睾丸山梨醇脱氢酶和酸性磷酸酶的活性降低，而乳酸脱氢酶、β-葡萄糖醛酸酶、葡萄糖-6-磷酸脱氢酶和γ-谷氨酰转肽酶的活性仅在暴露于200毫克/千克体重苯乙烯的动物中显著增加。结果表明，发育期间暴露于高剂量苯乙烯会改变与睾丸特定细胞类型相关的酶的活性。
