Albertsson Per A, Basse Per H, Hokland Marianne, Goldfarb Ronald H, Nagelkerke J Fred, Nannmark Ulf, Kuppen Peter J K
Department of Oncology, Sahlgrenska University Hospital, S-41345, Göteborg, Sweden.
Trends Immunol. 2003 Nov;24(11):603-9. doi: 10.1016/j.it.2003.09.007.
Although it is clear that natural killer (NK) cells have the ability to recognize and kill tumour cells in vitro, their potential as a highly effective treatment for tumours has not yet been realized in the clinical setting. Following activation, endogenous and adoptively transferred NK cells can be found in tumours. However, not all tumours are equally well-infiltrated, and many of the infiltrating cells do not make target-cell contact but rather reside in the tumour stroma. New insights into the migration of NK cells, their activation status and production of matrix-degrading proteases might help to overcome this localization defect, with implications for the treatment of human cancer.
虽然自然杀伤（NK）细胞在体外具有识别和杀伤肿瘤细胞的能力，但在临床环境中，其作为一种高效肿瘤治疗手段的潜力尚未得到实现。激活后，内源性和过继性转移的NK细胞可在肿瘤中被发现。然而，并非所有肿瘤都有同样良好的浸润情况，许多浸润细胞并不与靶细胞接触，而是存在于肿瘤基质中。对NK细胞迁移、其激活状态以及基质降解蛋白酶产生的新见解可能有助于克服这种定位缺陷，对人类癌症的治疗具有重要意义。
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