针对肿瘤微环境定制自然杀伤细胞免疫疗法。
Tailoring Natural Killer cell immunotherapy to the tumour microenvironment.
机构信息
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Semin Immunol. 2017 Jun;31:30-36. doi: 10.1016/j.smim.2017.09.001. Epub 2017 Sep 19.
Abstract
Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely compromised within the confines of the tumour microenvironment thus impairing the efficacy and development of NK cell-based therapies. Here we review the various cellular and molecular pathways that tumours have supplanted to evade NK cell surveillance. We highlight novel strategies designed to alleviate or circumvent the immunosuppressive conditions of the tumour microenvironment in order to emancipate NK cell function and stifle the inexorable growth and metastasis of malignant cells.
摘要
自然杀伤 (NK) 细胞是具有细胞毒性和细胞因子分泌功能的细胞，能够介导强大的抗肿瘤活性。越来越多的证据表明，NK 细胞功能在肿瘤微环境的限制下严重受损，从而削弱了基于 NK 细胞的治疗的疗效和发展。在这里，我们回顾了肿瘤逃避 NK 细胞监测的各种细胞和分子途径。我们强调了旨在减轻或规避肿瘤微环境免疫抑制条件的新策略，以释放 NK 细胞的功能并抑制恶性细胞的不可阻挡的生长和转移。
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