[三磷酸腺苷对早期个体发育过程中海马神经元振荡特性的调节作用]

[Modulating influence of adenosine triphosphate on the oscillating properties of hippocampal neurons during early ontogenesis].

作者信息

Safiulina V F, Kas'ianov A M, Sokolova E M, Mel'nik V I, Ezrokhi V L, Giniatullin R A

机构信息

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 2003 Jul-Aug;53(4):446-50.

PMID:14598552

Abstract

Extracellular ATP was used to test the involvement of purinergic P2 receptors in the modulation of GAB Aergic giant depolarizing potentials (GDPs) in rat neonatal hippocampus. Bath application of ATP reduced the GDP frequency in a concentration-dependent manner. The inhibitory effect of ATP persisted in the presence of adenosine P1 receptor antagonist DPCPX indicating the action of ATP on GDPs. It was suggested that, during development, ATP can modulate network-driven activity in the neonatal hippocampus through the activation of purinergic P2 receptors.

摘要

细胞外ATP被用于测试嘌呤能P2受体在调节新生大鼠海马体中γ-氨基丁酸能巨大去极化电位（GDPs）方面的作用。浴槽应用ATP以浓度依赖的方式降低了GDP的频率。在存在腺苷P1受体拮抗剂DPCPX的情况下，ATP的抑制作用仍然存在，这表明ATP对GDPs有作用。有人提出，在发育过程中，ATP可以通过激活嘌呤能P2受体来调节新生海马体中的网络驱动活动。