[Use of proton pump inhibitors in the treatment of gastroesophageal reflux disease].

Gastroesophageal reflux disease (GERD) is a wide spread disease characterized by distinct clinical polymorphism manifesting with various symptoms and/or inflammatory changes of a distal portion of the esophagus. Current first-line therapy in GERD consists in administration of proton pump inhibitors (PPI) which promote faster relief of the symptoms and healing of erosive-ulcerous lesions of esophageal mucosa in GERD patients. Clinical efficacy of standard and novel PPI is compared. Wide use of PPI and their long-term courses require further study of PPI side effects which now lack attention from the clinical researchers.