Lallana Enrico C, Abrey Lauren E
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Expert Rev Anticancer Ther. 2003 Oct;3(5):655-70. doi: 10.1586/14737140.3.5.655.
Neuro-oncology is a rapidly growing field of study. The understanding of brain tumors has expanded in pace with advances in the field of molecular biology and genetics. Diagnoses are more accurate, biopsy and surgical intervention safer, radiotherapy more focused and chemotherapy safer and better tolerated. Novel strategies based on the understanding of brain tumor biology are emerging as targeted approaches to therapy. Despite all this, only a minority of patients with certain subsets of brain tumors have experienced prolonged survival. This review focuses on the standard and emerging therapies for the two most common categories of brain tumors: gliomas and meningiomas. Primary CNS lymphoma, while a relatively rare tumor, is also included as a topic of discussion as the achievements in its treatment represent the principal strides in the evolution of neuro-oncology.
神经肿瘤学是一个快速发展的研究领域。随着分子生物学和遗传学领域的进展,对脑肿瘤的认识也在不断扩展。诊断更加准确,活检和手术干预更安全,放射治疗更具针对性,化疗更安全且耐受性更好。基于对脑肿瘤生物学的理解而产生的新策略正在成为靶向治疗方法。尽管如此,只有少数患有某些类型脑肿瘤的患者实现了长期生存。本综述重点关注两种最常见脑肿瘤类型:胶质瘤和脑膜瘤的标准治疗方法和新兴治疗方法。原发性中枢神经系统淋巴瘤虽然是一种相对罕见的肿瘤,但也作为一个讨论主题纳入其中,因为其治疗方面的成就代表了神经肿瘤学发展的主要进展。