Innis R B
Department of Psychiatry, Yale University, School of Medicine, Conn.
J Clin Psychiatry. 1992 Nov;53 Suppl:29-34.
Single photon emission computed tomography (SPECT) imaging can provide useful measurements of brain receptors and endogenous neurotransmitters and may have significant experimental and clinical applications. This presentation reviews the use of SPECT for neuroreceptor imaging. Studies of receptors for benzodiazepines, dopamine D2 agents, and dopamine reuptake sites will be used to exemplify the capabilities of SPECT. Tracers labeled with the radioisotope 125I have high affinity, high brain uptake, and high ratios of specific to nonspecific binding. Imaging studies of human and nonhuman primate brain will be presented, and the potential clinical applicability of these agents will be discussed.
单光子发射计算机断层扫描（SPECT）成像能够对脑受体和内源性神经递质进行有效的测量，并且可能具有重要的实验和临床应用价值。本报告回顾了SPECT在神经受体成像方面的应用。以苯二氮䓬类、多巴胺D2受体激动剂和多巴胺再摄取位点的受体研究为例，阐述SPECT的功能。用放射性同位素125I标记的示踪剂具有高亲和力、高脑摄取率以及高特异性与非特异性结合比率。将展示人类和非人灵长类动物脑的成像研究，并讨论这些药物潜在的临床适用性。
