Zehnder Matthias, Grawehr Matthias, Hasselgren Gunnar, Waltimo Tuomas
University of Zürich, University of Zürich Center for Dental Medicine, Division of Preventive Dentistry, Cariology and Periodontology, Zürich, Switzerland.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Nov;96(5):608-13. doi: 10.1016/s1079-2104(03)00157-4.
The goal of this study was to compare the tissue-dissolution potential and antibacterial effectiveness of a conventional Ca(OH)(2)/saline paste with equivalent Ca(OH)(2)/NaOCl and Ca(OH)(2)/chlorhexidine digluconate medications.
Tissue specimens were obtained from freshly dissected pig palates. Tissue pieces of similar form and weight were incubated in air-tight containers with Ca(OH)(2) pastes or solutions proper for up to 7 days. Antimicrobial testing was performed in dentin blocks infected with Enterococcus faecalis. Medicated, sealed dentin specimens were incubated for 1 and 5 days, and bacterial growth was tested at different dentin depths.
Up to day 4, the Ca(OH)(2)/irrigating solution mixtures dissolved tissue more effectively than the conventional Ca(OH)(2)/saline paste. After 7 days, however, no statistically significant differences were found between the saline and hypochlorite mixtures, but the Ca(OH)(2)/chlorhexidine medication was significantly less effective. Dentin block disinfection was quicker and more thorough with the Ca(OH)(2)/chlorhexidine or the Ca(OH)(2)/NaOCl than with the Ca(OH)(2)/saline paste.
Ca(OH)(2)/irrigant mixtures under investigation appear more advantageous than the conventional Ca(OH)(2)/saline mixture, and merit further investigation in a clinical study.
本研究的目的是比较传统的Ca(OH)₂/生理盐水糊剂与等量的Ca(OH)₂/次氯酸钠及Ca(OH)₂/葡萄糖酸氯己定药物的组织溶解潜力和抗菌效果。
从刚解剖的猪腭部获取组织标本。将形状和重量相似的组织块置于密封容器中，与Ca(OH)₂糊剂或适当的溶液一起孵育长达7天。在感染粪肠球菌的牙本质块中进行抗菌测试。将含药的密封牙本质标本孵育1天和5天，并在不同牙本质深度测试细菌生长情况。
直至第4天，Ca(OH)₂/冲洗液混合物比传统的Ca(OH)₂/生理盐水糊剂更有效地溶解组织。然而，7天后，生理盐水和次氯酸盐混合物之间未发现统计学上的显著差异，但Ca(OH)₂/葡萄糖酸氯己定药物的效果明显较差。与Ca(OH)₂/生理盐水糊剂相比，Ca(OH)₂/葡萄糖酸氯己定或Ca(OH)₂/次氯酸钠对牙本质块的消毒更快、更彻底。
所研究的Ca(OH)₂/冲洗剂混合物似乎比传统的Ca(OH)₂/生理盐水混合物更具优势，值得在临床研究中进一步研究。
