Oldereid Nan B, Abyholm Thomas, Tanbo Tom, Engelund Inger Elise, Irgens Lorentz M
Kvinneklinikken, Rikshospitalet, Oslo.
Tidsskr Nor Laegeforen. 2003 Oct 9;123(19):2696-9.
The aim of this study was to compare the prevalence at birth of birth defects in children born after intracytoplasmatic sperm injection (ICSI) and children born after traditional in vitro fertilisation (IVF). Altogether 553 children were born after ICSI treatment in Norway during the period 1996-1998 (351 singletons, 95 twins-pairs and 4 triplets) while 1731 were born after IVF treatment (1004 singletons, 344 sets of twins and 13 triplets). Birth defects were registered in 5.42% of children born after ICSI and in 5.14% of children born after IVF; 3,07% and 3.00% respectively were major birth defects. We conclude that intracytoplasmic sperm injection does not imply a significant increase in the prevalence at birth of birth defects compared to children conceived by traditional IVF.
本研究的目的是比较卵胞浆内单精子注射（ICSI）后出生的儿童与传统体外受精（IVF）后出生的儿童出生时出生缺陷的患病率。1996年至1998年期间，挪威共有553名儿童在ICSI治疗后出生（351名单胎、95对双胞胎和4例三胞胎），而1731名儿童在IVF治疗后出生（1004名单胎、344对双胞胎和13例三胞胎）。ICSI后出生的儿童中5.42%登记有出生缺陷，IVF后出生的儿童中这一比例为5.14%；严重出生缺陷分别为3.07%和3.00%。我们得出结论，与传统IVF受孕的儿童相比，卵胞浆内单精子注射并不意味着出生时出生缺陷患病率显著增加。
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