Mau C, Juul A, Main K M, Loft A
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
Acta Paediatr. 2004 Sep;93(9):1238-44.
The aim of the study was to evaluate current medical knowledge about children born after intracytoplasmic sperm injection (ICSI) with respect to congenital malformations, chromosome abnormalities and postnatal growth.
The total malformation rate in children conceived after ICSI was comparable to the background population in nine of the 11 articles studied. In two of the studies, a significant increase in congenital malformations was found. More specifically, children born after ICSI appear to have a higher risk of urogenital malformations, especially hypospadias, which may be related to paternal subfertility. There is insufficient knowledge about chromosomal or genetic anomalies and auxological data in children born after ICSI. The methodological approach to follow-up the children was inconsistent, as the clinical examinations were not done with standardized ascertainment.
Paediatricians and obstetricians should collaborate with fertility clinics to obtain valid longitudinal observations with respect to congenital malformations, neurological development, growth, pubertal maturation, fertility and morbidity in children conceived by ICSI.
本研究旨在评估目前关于卵胞浆内单精子注射（ICSI）后出生儿童的先天性畸形、染色体异常和出生后生长发育方面的医学知识。
在11篇研究文章中的9篇里，ICSI后受孕儿童的总畸形率与背景人群相当。在两项研究中，发现先天性畸形显著增加。更具体地说，ICSI后出生的儿童似乎有更高的泌尿生殖系统畸形风险，尤其是尿道下裂，这可能与父方生育力低下有关。关于ICSI后出生儿童的染色体或基因异常以及生长发育数据的了解不足。对这些儿童进行随访的方法不一致，因为临床检查并非采用标准化的确诊方式。
儿科医生和产科医生应与生殖诊所合作，以获得关于ICSI受孕儿童的先天性畸形、神经发育、生长、青春期成熟、生育能力和发病率的有效纵向观察结果。
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