前列腺癌基因位于何处？——八项全基因组搜索综述
Where are the prostate cancer genes?--A summary of eight genome wide searches.
作者信息
Easton Douglas F, Schaid Daniel J, Whittemore Alice S, Isaacs William J
机构信息
Cancer Research U.K. Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom.
出版信息
Prostate. 2003 Dec 1;57(4):261-9. doi: 10.1002/pros.10300.
BACKGROUND
There is strong evidence for genetic susceptibility to prostate cancer, but most of the genes underlying this susceptibility remain to be identified.
METHODS
We reviewed the results of eight genome-wide linkage searches based on 1,293 families with multiple cases of prostate cancer.
RESULTS
Across these studies, 11 linkage peaks with LOD scores in excess of 2 were identified. However, no chromosomal region was reported as significant at this level by more than one study and only one corresponded to a peak previously suggested by another group.
CONCLUSIONS
These results indicate that prostate cancer is genetically complex, and that combined analyses of large family sets will be required to evaluate reliably the linkage evidence.
背景
有强有力的证据表明前列腺癌存在遗传易感性，但这种易感性背后的大多数基因仍有待确定。
方法
我们回顾了基于1293个有多例前列腺癌病例的家族进行的八项全基因组连锁搜索结果。
结果
在这些研究中，确定了11个对数优势分数（LOD）超过2的连锁峰。然而，没有一个染色体区域在这个水平上被不止一项研究所报道为显著，并且只有一个与另一组先前提出的峰相对应。
结论
这些结果表明前列腺癌在遗传上是复杂的，需要对大型家族集进行联合分析才能可靠地评估连锁证据。
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