Díaz Florentina, Moreno Paloma, Villena Alicia, Vidal Lourdes, Pérez De Vargas Ignacio
Department of Histology and Pathology, School of Medicine, University of Málaga, 29071 Málaga, Spain.
Microsc Res Tech. 2003 Dec 1;62(5):431-8. doi: 10.1002/jemt.10404.
The aim of this study was to investigate the effect of aging on glial cells and neurons from the superficial layers of the superior colliculus in rats. We used stereological methods to estimate the volume of the superficial layers, neuron size, and the number of neurons and glial cells in Wistar male rats aged 3, 24, 26, and 28 months. A 32.6% volume increase was found in the stratum griseum superficiale between the ages of 3 and 26 months, while in the 28-month-old animals a 19% decrease was observed. The stratum opticum did not show any changes in volume with age. Also, our analysis revealed a process of somatic and nuclear atrophy in the neurons of the superficial layers in animals aged 26 and 28 months. On the other hand, no statistically significant differences were found in the numbers of neurons. The number of glial cells in the stratum griseum superficiale showed an increase between the 3rd and 26th month, while the stratum opticum suffered no change.
本研究的目的是调查衰老对大鼠上丘表层神经胶质细胞和神经元的影响。我们采用体视学方法评估3、24、26和28月龄雄性Wistar大鼠上丘表层的体积、神经元大小以及神经元和神经胶质细胞的数量。在3至26月龄之间，浅层灰质体积增加了32.6%，而在28月龄的动物中，观察到体积减少了19%。视层体积未随年龄出现任何变化。此外，我们的分析揭示了26和28月龄动物表层神经元的体细胞和细胞核萎缩过程。另一方面，在神经元数量上未发现统计学显著差异。浅层灰质中的神经胶质细胞数量在第3个月至第26个月之间有所增加，而视层则没有变化。
