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产科大出血

Massive obstetric hemorrhage.

作者信息

Papp Zoltán

机构信息

I. Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.

出版信息

J Perinat Med. 2003;31(5):408-14. doi: 10.1515/JPM.2003.063.

Abstract

Massive obstetric haemorrhage is a major cause of maternal death and morbidity; abruption of the placenta, placenta praevia and postpartum haemorrhage being the main causes of haemorrhages. A delay in the correction of hypovolaemia, diagnosis and treatment of defective coagulation and/or surgical control of bleeding are the avoidable factors in most maternal deaths caused by haemorrhage. The main goal is to maintain effective circulating intravascular volume by prompt and adequate replacement of blood, crystalloids or fresh-frozen plasma through more than one intravenous line (it might be necessary to pump blood under pressure) with constant monitoring of the pulse rate and the arterial blood pressure. The rapid correction of hypovolaemia with crystalloids and red cells is the first priority, followed by blood component therapy. Oxytocin and prostaglandin will correct uterine atony, and appropriate surgical intervention is required for traumatic bleeding. Ligation of the uterine arteries, ovarian arteries and hypogastric arteries will usually control uterine bleeding and arterial embolization is also effective. Hysterectomy should also be considered in severe cases. All gynecologists should be able to perform without delay the operative maneuvers which are necessary to control the bleeding, including hypogastric artery ligation, or even emergency hysterectomy. This topic may have received little attention because it is perceived as being associated with maternal morbidity rather than mortality in developed countries; it is only recently that the extent and importance of postnatal maternal morbidity has been recognized.

摘要

产科大出血是孕产妇死亡和发病的主要原因;胎盘早剥、前置胎盘和产后出血是出血的主要原因。低血容量纠正延迟、凝血功能障碍的诊断和治疗以及出血的手术控制是大多数因出血导致的孕产妇死亡中可避免的因素。主要目标是通过多条静脉通路迅速、充分地补充血液、晶体液或新鲜冷冻血浆(可能需要加压输血)来维持有效的循环血容量,同时持续监测脉搏率和动脉血压。首先要迅速用晶体液和红细胞纠正低血容量,随后进行血液成分治疗。缩宫素和前列腺素可纠正子宫收缩乏力,对于创伤性出血则需要进行适当的手术干预。结扎子宫动脉、卵巢动脉和腹下动脉通常可控制子宫出血,动脉栓塞也有效。在严重病例中还应考虑行子宫切除术。所有妇科医生都应能够立即进行控制出血所需的手术操作,包括结扎腹下动脉,甚至紧急子宫切除术。这个话题可能很少受到关注,因为在发达国家它被认为与孕产妇发病而非死亡相关;直到最近,产后孕产妇发病的程度和重要性才得到认可。

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