Comte Frédéric, De Rosa Vicenzo, Zekri Hakim, Eberlé Marie Claude, Dimeglio Alain, Rossi Michel, Mariano-Goulart Denis
Service de Médecine Nucléaire, Centre Hospitalier Universitaire de Montpellier, Montpellier, France.
J Nucl Med. 2003 Nov;44(11):1761-6.
In about half of all patients with Legg-Calvé-Perthes disease (LCP), severe hip disorders that could be prevented by early surgery will develop. A prognostic test for this complication is also needed as part of routine care to help the surgeon manage LCD. The purpose of this study was to confirm the prognostic value of the bone scanning and pinhole imaging of the hip in LCP that Conway's group proposed in 1997 and to define accurate prognostic scintigraphic patterns.
Fifty-eight patients with LCP were recruited at initial presentation and followed for 1 y. Each patient underwent bone scanning initially and after 5, 8, and 12 mo of disease. The severity of the disease was assessed by radiography (the Catterall classification), MRI, and arthrography. Retrospectively, initial scintigraphic findings were correlated with severity.
Among the 60 hips studied (2 patients had bilateral disease), severe hip disorders developed in 36. The positive predictive value of the scintigraphic classification proposed by Conway's group was 97% for the B pathway (absence of lateral column formation) and 85% for the A pathway (presence of lateral column formation). The hyperactivity of the metaphyseal growth plates was a sign of poor prognosis. The sensitivity was only 33%, but the positive predictive value was 92%. This prognostic information was obtained in as few as 5 mo after initial presentation.
This study confirms the high prognostic value of bone scanning in LCP as reported by Conway's group not only in terms of the accuracy of the classification but also in terms of the short time in which the prognostic information can be obtained. Thus, we propose that bone scanning be used as part of routine care for the management of LCP.
在大约一半的Legg-Calvé-Perthes病(LCP)患者中,会出现可通过早期手术预防的严重髋关节疾病。作为常规护理的一部分,也需要一种针对这种并发症的预后测试,以帮助外科医生管理LCP。本研究的目的是证实Conway团队在1997年提出的LCP患者髋关节骨扫描和针孔成像的预后价值,并确定准确的预后闪烁造影模式。
58例LCP患者在初次就诊时被招募,并随访1年。每位患者在疾病初发时以及发病5、8和12个月后均接受骨扫描。通过X线摄影(Catterall分类)、MRI和关节造影评估疾病的严重程度。回顾性地将初始闪烁造影结果与严重程度进行关联。
在研究的60个髋关节中(2例患者为双侧患病),36个出现了严重的髋关节疾病。Conway团队提出的闪烁造影分类对于B型路径(外侧柱未形成)的阳性预测值为97%,对于A型路径(外侧柱形成)为85%。干骺端生长板的活性增强是预后不良的迹象。其敏感性仅为33%,但阳性预测值为92%。在初次就诊后短短5个月内即可获得这种预后信息。
本研究证实了Conway团队报道的骨扫描在LCP中的高预后价值,不仅体现在分类的准确性上,还体现在可获得预后信息的短时间内。因此,我们建议将骨扫描用作LCP管理常规护理的一部分。