Spitzer S, Bach R, Schieffer H
Medical Clinic, University Hospitals of the Saarland, Homburg-Saar, Germany.
Int Angiol. 1992 Jul-Sep;11(3):204-10.
On the basis of the present studies physical therapy is the most effective basis therapy of peripheral arterial occlusive disease stage II according to Fontaine. The consequent integration of the patients into widespread vascular training groups would be desirable. All present studies with so-called vasoactive drugs led to a statistically significant increase in pain-free walking distance. This is especially true for the substances naftidrofuryl, pentoxifylline, and buflomedil. Nevertheless, these studies do not fully meet the standards set by the GCP or the FDA guidelines. It must also be said that the increase in walking distance by vasoactive substances is less pronounced than the effect obtained by walk training alone. Both the vasoactive therapy and controlled walk training aim at an increase in pain-free walking distance. It is, however, still unclear whether the modes of therapy described influence the primary disease. Angiographically controlled studies are momentarily not available.
基于目前的研究，物理治疗是根据Fontaine分级法对II期外周动脉闭塞性疾病最有效的基础治疗方法。因此，将患者纳入广泛的血管训练组是可取的。所有目前关于所谓血管活性药物的研究均导致无痛步行距离在统计学上显著增加。对于萘呋胺酯、己酮可可碱和丁咯地尔这些药物来说尤其如此。然而，这些研究并未完全符合GCP或FDA指南所设定的标准。还必须指出的是，血管活性物质使步行距离增加的程度不如单纯步行训练所获得的效果明显。血管活性治疗和有控制的步行训练都旨在增加无痛步行距离。然而，目前仍不清楚所描述的治疗方式是否会影响原发性疾病。目前尚无血管造影控制的研究。
