Breuer Jan-Philipp, Neumann Tim, Heinz Andreas, Kox Wolfgang J, Spies Claudia
Klinik für Anästhesiologie und operative Intensivmedizin, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Gemeinsame Einrichtung von Freier Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Deutschland.
Wien Klin Wochenschr. 2003 Sep 30;115(17-18):618-33. doi: 10.1007/BF03040467.
Chronic alcohol abuse is of significant clinical and economic relevance. A major part of internal medical pathology is associated with chronic alcoholism. 50% of all accidents with subsequent traumatic injuries are related to alcohol intake. Patients who are chronic alcohol abusers have prolonged hospital stays and substantial increases in postoperative morbidity. A sophisticated diagnosis of alcoholism within standard clinical routine is often difficult, and in most cases the treatment of alcohol-related diseases and complications is protracted and requires increased energy expenditure by the treating physicians. In surgical patients, chronic alcohol abuse is associated with a 3- to 4-fold risk of infections, sepsis, cardiac and bleeding complications. Therefore, the patients themselves, along with the general practitioner and an in-hospital interdisciplinary team should cooperate in medical and operative treatment in order to attain better clinical outcome. Each patient history should include a detailed assessment of the quantity of daily alcohol intake. Alcoholic diagnostic regimens including questionnaires (i.e. CAGE, AUDIT) in combination with specific laboratory markers (CDT, GGT, MCV), if implemented, could prove valuable, especially in cases where major surgical procedures are considered. Strict abstinence by alcoholic patients with organ pathology in medical and elective surgical settings as well as the prophylactic treatment of pre-operative alcohol withdrawal appear to be useful strategies to reduce the risk of complications. Short-term interventions are associated with reduced alcohol intake and decreased incidence of re-trauma. Considering the clinical relevance of alcohol abuse, sufficient screening, interventions, and open approaches to address alcohol problems should be important components of the daily clinical routine in outpatient clinics, emergency rooms, in GPs' offices and in general hospitals.
长期酗酒具有重大的临床和经济意义。内科病理学的很大一部分与慢性酒精中毒有关。所有后续有创伤性损伤的事故中,50%与饮酒有关。慢性酗酒患者住院时间延长,术后发病率大幅增加。在标准临床常规中对酒精中毒进行精确诊断往往很困难,而且在大多数情况下,与酒精相关疾病和并发症的治疗过程漫长,需要治疗医生付出更多精力。在外科手术患者中,慢性酗酒会使感染、败血症、心脏和出血并发症的风险增加3至4倍。因此,患者本人应与全科医生及医院内的跨学科团队合作进行药物和手术治疗,以获得更好的临床效果。每份患者病历都应包括对每日饮酒量的详细评估。如果实施包括问卷(如CAGE、AUDIT)以及特定实验室指标(CDT、GGT、MCV)在内的酒精诊断方案,可能会很有价值,尤其是在考虑进行大型外科手术的情况下。患有器官病变的酗酒患者在接受药物治疗和择期手术时严格戒酒,以及对术前酒精戒断进行预防性治疗,似乎是降低并发症风险的有效策略。短期干预与饮酒量减少和再次受伤发生率降低有关。鉴于酗酒的临床相关性,充分的筛查、干预以及解决酒精问题的开放方法应成为门诊诊所、急诊室、全科医生办公室和综合医院日常临床工作的重要组成部分。