胎儿型DJH连接在B前体淋巴细胞白血病幼儿中占优势，提示子宫内存在转化事件。
Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event.
作者信息
Wasserman R, Galili N, Ito Y, Reichard B A, Shane S, Rovera G
机构信息
Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania.
出版信息
J Exp Med. 1992 Dec 1;176(6):1577-81. doi: 10.1084/jem.176.6.1577.
Abstract
The presence of N sequences in the complementarity determining region 3 (CDR3) of the rearranged immunoglobulin H chain is developmentally regulated: N regions are generally present in the DJH joinings of adult B cells but are often absent in fetal B cells. Analysis of the CDR3 in 61 B precursor acute lymphoblastic leukemias indicated that 87.5% of the leukemias obtained from children < or = 3 yr old lacked N regions at the DJH junction. In contrast, in children > 3 yr old, only 11.1% of the leukemias lacked N regions at this junction, a frequency similar to what we have observed in B cells from children and adults. These findings suggest that the majority of leukemias presenting within the first 3 yr of age arise from an in utero transforming event.
摘要
重排免疫球蛋白H链互补决定区3（CDR3）中N序列的存在受发育调控：N区通常存在于成年B细胞的DJH连接中，但在胎儿B细胞中常不存在。对61例B前体急性淋巴细胞白血病的CDR3分析表明，87.5%来自3岁及以下儿童的白血病在DJH连接处缺乏N区。相比之下，在3岁以上儿童中，只有11.1%的白血病在该连接处缺乏N区，这一频率与我们在儿童和成人B细胞中观察到的相似。这些发现表明，大多数在3岁内出现的白血病源自子宫内的转化事件。
相似文献
1
Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event.胎儿型DJH连接在B前体淋巴细胞白血病幼儿中占优势，提示子宫内存在转化事件。
J Exp Med. 1992 Dec 1;176(6):1577-81. doi: 10.1084/jem.176.6.1577.
2
B precursor acute lymphoblastic leukemia third complementarity-determining regions predominantly represent an unbiased recombination repertoire: leukemic transformation frequently occurs in fetal life.B前体急性淋巴细胞白血病的第三互补决定区主要代表一种无偏向性的重排库：白血病转化常发生于胎儿期。
Eur J Immunol. 1994 Apr;24(4):900-8. doi: 10.1002/eji.1830240418.
3
4
5
Size and frequency of the DNA fragments in the rearranged immunoglobulin heavy chain joining regions in the lymphocytic leukemias.
Anticancer Res. 1991 Mar-Apr;11(2):813-6.
6
Clonal evolution as judged by immunoglobulin heavy chain gene rearrangements in relapsing precursor-B acute lymphoblastic leukemia.通过免疫球蛋白重链基因重排判断复发性前体B淋巴细胞急性淋巴细胞白血病中的克隆进化。
Eur J Haematol. 1999 Sep;63(3):171-9. doi: 10.1111/j.1600-0609.1999.tb01765.x.
7
Comparative sequence analysis of incomplete DJH and TCR gene rearrangements in children with relapses of T-ALL.T 细胞急性淋巴细胞白血病复发患儿中不完全 DJH 和 TCR 基因重排的比较序列分析
Leukemia. 2005 Sep;19(9):1687-9. doi: 10.1038/sj.leu.2403878.
8
[Characteristics of immunoglobulin heavy chain variable region genes in childhood B-cell acute lymphoblastic leukemia].儿童B细胞急性淋巴细胞白血病免疫球蛋白重链可变区基因特征
Zhonghua Xue Ye Xue Za Zhi. 2004 Jan;25(1):8-12.
9
Presence of N regions in the clonotypic DJ rearrangements of the immunoglobulin heavy-chain genes indicates an exquisitely short latency in t(4;11)-positive infant acute lymphoblastic leukemia.免疫球蛋白重链基因克隆型DJ重排中N区域的存在表明t(4;11)阳性婴儿急性淋巴细胞白血病的潜伏期极短。
Blood. 2001 Oct 1;98(7):2272-4. doi: 10.1182/blood.v98.7.2272.
10
Ordered rearrangement of immunoglobulin heavy chain variable region segments.免疫球蛋白重链可变区片段的有序重排。
EMBO J. 1984 Jun;3(6):1209-19. doi: 10.1002/j.1460-2075.1984.tb01955.x.
引用本文的文献
1
Decreased IL7Rα and TdT expression underlie the skewed immunoglobulin repertoire of human B-cell precursors from fetal origin.IL7Rα和末端脱氧核苷酸转移酶（TdT）表达降低是源自胎儿的人类B细胞前体免疫球蛋白库偏向性的基础。
Sci Rep. 2016 Sep 23;6:33924. doi: 10.1038/srep33924.
2
Occurrence of ²¹⁰Po and biological effects of low-level exposure: the need for research.²¹⁰Po 的出现及低水平暴露的生物学效应：研究的必要性。
Environ Health Perspect. 2012 Sep;120(9):1230-7. doi: 10.1289/ehp.1104607. Epub 2012 Apr 26.
3
Perspectives on the causes of childhood leukemia.儿童白血病病因的研究进展。
Chem Biol Interact. 2012 Apr 5;196(3):59-67. doi: 10.1016/j.cbi.2012.01.007. Epub 2012 Feb 2.
4
Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways.在两条前 B 细胞发育途径中，对人 CD34+CD10-CD19+前/祖 B 细胞和 CD19-common lymphoid 祖细胞阶段进行排序。
Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5925-30. doi: 10.1073/pnas.0907942107. Epub 2010 Mar 15.
5
Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia.儿童急性淋巴细胞白血病中t(1;19) E2A-PBX1融合基因的位点特异性易位及产后起源证据
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15101-6. doi: 10.1073/pnas.222481199. Epub 2002 Nov 1.
6
Immunoglobulin variable region structure and B-cell malignancies.免疫球蛋白可变区结构与B细胞恶性肿瘤
Int J Hematol. 2001 Jan;73(1):47-53. doi: 10.1007/BF02981902.
7
Establishment of a novel B cell clonality analysis using single-strand conformation polymorphism of immunoglobulin light chain messenger signals.利用免疫球蛋白轻链信使信号的单链构象多态性建立一种新型B细胞克隆性分析方法。
Am J Pathol. 1998 Nov;153(5):1393-400. doi: 10.1016/S0002-9440(10)65726-4.
8
Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia.患有白血病的同卵双胞胎中TEL-AML1融合基因的胎儿起源。
Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4584-8. doi: 10.1073/pnas.95.8.4584.
9
Big babies and infant leukemia: a role for insulin-like growth factor-1?巨大儿与婴儿白血病：胰岛素样生长因子-1发挥了作用？
Cancer Causes Control. 1996 Sep;7(5):553-9. doi: 10.1007/BF00051889.
10
Mechanistic constraints on diversity in human V(D)J recombination.人类V(D)J重组多样性的机制性限制
Mol Cell Biol. 1996 Jan;16(1):258-69. doi: 10.1128/MCB.16.1.258.
本文引用的文献
1
Clonal proliferation unlinked to terminal deoxynucleotidyl transferase synthesis in thymocytes of young mice.年轻小鼠胸腺细胞中与末端脱氧核苷酸转移酶合成无关的克隆增殖。
J Immunol. 1983 Apr;130(4):1627-33.
2
Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.T细胞和B细胞前体起源的急性淋巴细胞白血病中的免疫球蛋白基因重排及细胞表面抗原表达
J Clin Invest. 1983 Feb;71(2):301-13. doi: 10.1172/jci110770.
3
B cell origin of non-T cell acute lymphoblastic leukemia. A model for discrete stages of neoplastic and normal pre-B cell differentiation.非T细胞急性淋巴细胞白血病的B细胞起源。肿瘤性和正常前B细胞分化离散阶段的模型。
J Clin Invest. 1984 Aug;74(2):332-40. doi: 10.1172/JCI111428.
4
The development of immunoglobulin levels in man.
J Pediatr. 1968 Feb;72(2):276-90. doi: 10.1016/s0022-3476(68)80324-5.
5
Differentiation-linked leukemogenesis in lymphocytes.淋巴细胞中与分化相关的白血病发生
Science. 1986 Nov 7;234(4777):697-704. doi: 10.1126/science.3535067.
6
Speculations on the cause of childhood acute lymphoblastic leukemia.关于儿童急性淋巴细胞白血病病因的推测。
Leukemia. 1988 Feb;2(2):120-5.
7
Immunologic classification of leukemia and lymphoma.白血病和淋巴瘤的免疫分类
Blood. 1986 Jul;68(1):1-31.
8
The mechanism of antigen receptor gene assembly.抗原受体基因组装的机制。
Cell. 1989 Nov 17;59(4):585-8. doi: 10.1016/0092-8674(89)90002-0.
9
The V(D)J recombination activating gene, RAG-1.V(D)J重组激活基因，RAG-1。
Cell. 1989 Dec 22;59(6):1035-48. doi: 10.1016/0092-8674(89)90760-5.
10
Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.T细胞受体γδ基因的连接序列：对γδ T细胞谱系及V-(D)-J连接新中间体的影响
Cell. 1989 Dec 1;59(5):859-70. doi: 10.1016/0092-8674(89)90609-0.
Zotero 插件