Hall Andrew J, Achilli Laura, Manesiotis Panagiotis, Quaglia Milena, De Lorenzi Ersilia, Sellergren Börje
Institut für Anorganische Chemie und Analytische Chemie, Johannes Gutenberg Universität, Duesbergweg 10-14, D-55099, Mainz, Germany.
J Org Chem. 2003 Nov 14;68(23):9132-5. doi: 10.1021/jo034588e.
The preparation of a molecularly imprinted polymer against N-Z-L-glutamic acid using a novel bis-urea functional monomer is described. The polymer exhibits affinity for the template over N-Z-protected aspartic acid and glycine and, further, is capable of binding larger molecules, e.g., the anti-cancer drug methotrexate, containing the glutamate substructure.
描述了使用一种新型双脲功能单体制备针对N-Z-L-谷氨酸的分子印迹聚合物。该聚合物对模板的亲和力高于N-Z保护的天冬氨酸和甘氨酸，并且还能够结合含有谷氨酸亚结构的更大分子，例如抗癌药物甲氨蝶呤。
