Radlanski R J
Department of Experimental Dentistry, University Clinic, Benjamin Franklin at Freie Universität Berlin, Berlin, Germany.
Orthod Craniofac Res. 2003;6 Suppl 1:89-94. doi: 10.1034/j.1600-0544.2003.240.x.
Basic research concerning craniofacial development presently runs along two pathways, namely the molecular and the morphometric. This gap needs to be bridged.
Using histological serial sections of human fetuses computer-aided three-dimensional reconstructions were made (Software Analysis, SIS) with special focus given to all anatomical structures of the orofacial region of the growing head.
All reconstructions can be viewed from any rotation and they are available for virtual dissection according to anatomical rules. As an example, the prenatal development of the human mandible with the formation of the mental foramen therein is described. Furthermore, the spatial arrangement of bone, cartilage and nerves is presented in three dimensions in different developmental stages. The interaction of tissues with possible morphogenetic interaction is discussed.
This work serves as a reference system for prenatal development in comparison with pathological development.
目前关于颅面发育的基础研究沿着两条路径进行，即分子路径和形态测量路径。这种差距需要弥合。
利用人类胎儿的组织学连续切片进行计算机辅助三维重建（软件分析，SIS），特别关注生长头部口面部区域的所有解剖结构。
所有重建图像均可从任何角度查看，并可根据解剖规则进行虚拟解剖。例如，描述了人类下颌骨的产前发育及其内部颏孔的形成。此外，还展示了不同发育阶段骨、软骨和神经的三维空间排列。讨论了组织间可能的形态发生相互作用。
这项工作作为产前发育与病理发育对比的参考系统。
