Modi William S, Serdyukova Natalya A, Vorobieva Nadezhda V, Graphodatsky Alexander S
Basic Research Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Chromosome Res. 2003;11(7):705-13. doi: 10.1023/a:1025922813756.
C-banding and fluorescence in situ hybridization (FISH) document the distribution of constitutive heterochromatin and six highly repeated DNA families (MSAT2570, MSAT21, MSAT160, MS2, MS4 and STR47) in the chromosomes of nine species of Microtus (M. chrotorrhinus, M. rossiaemeridionalis, M. arvalis, M. ilaeus, M. transcaspicus, M. cabrerae, M. pennsylvanicus, M. miurus and M. ochrogaster). Autosomal heterochromatin is largely centromeric and contains different repeated families in different species. Similarly, large C-band positive blocks on the sex chromosomes of four species contain different repeated DNAs. This interspecific variation in the chromosomal distribution and copy number of the repeats suggests that a common ancestor to modern species contained most of the repetitive families, and that descendant species selectively amplified or deleted different repeats on different chromosomes.
C带和荧光原位杂交（FISH）技术记录了九种田鼠（棕色田鼠、南俄田鼠、普通田鼠、伊氏田鼠、里海田鼠、卡氏田鼠、宾夕法尼亚田鼠、小田鼠和橙腹田鼠）染色体上组成型异染色质和六个高度重复DNA家族（MSAT2570、MSAT21、MSAT160、MS2、MS4和STR47）的分布情况。常染色体异染色质主要位于着丝粒区域，且在不同物种中包含不同的重复家族。同样，四种田鼠性染色体上的大C带阳性区域含有不同的重复DNA。这些重复序列在染色体分布和拷贝数上的种间差异表明，现代物种的共同祖先包含了大多数重复家族，而后代物种在不同染色体上选择性地扩增或删除了不同的重复序列。
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