Koido S, Shimoda T
Department of Pathology, Jikei University School of Medicine, Tokyo.
Nihon Shokakibyo Gakkai Zasshi. 1992 Nov;89(11):2664-72.
The distribution of proliferating cells was studied in colorectal carcinoma by immunohistochemistry using monoclonal antibody-DNA polymerase alpha and Ki-67. Colorectal carcinoma was classified into two types by growth mode: (1) intramucosal polypoid growth carcinoma and (2) non-polypoid growth carcinoma. The labeling index of anti-DNA polymerase alpha and Ki-67 in non-polypoid growth carcinoma was significantly higher than in polypoid growth carcinoma. The labeling index of polypoid growth carcinoma was significantly higher than adenoma. The proliferating cells in polypoid growth carcinoma and adenoma were mainly distributed in the upper third of intramucosal neoplastic gland. However, in non-polypoid growth carcinoma, the proliferating cells of intramucosal lesion were scattered mainly in the lower third along the neoplastic gland. The distribution pattern of proliferating cells in early carcinoma with non-polypoid growth were similar to those of non-polypoid growth advanced carcinoma. These results suggested that submucosal invasion occurred more rapidly in intramucosal non-polypoid growth carcinoma.
采用单克隆抗体-DNA聚合酶α和Ki-67，通过免疫组织化学方法研究了结肠直肠癌中增殖细胞的分布情况。结肠直肠癌根据生长方式分为两种类型：（1）黏膜内息肉样生长癌和（2）非息肉样生长癌。非息肉样生长癌中抗DNA聚合酶α和Ki-67的标记指数显著高于息肉样生长癌。息肉样生长癌的标记指数显著高于腺瘤。息肉样生长癌和腺瘤中的增殖细胞主要分布在黏膜内肿瘤性腺体的上三分之一处。然而，在非息肉样生长癌中，黏膜内病变的增殖细胞主要沿肿瘤性腺体散在于下三分之一处。非息肉样生长早期癌中增殖细胞的分布模式与非息肉样生长进展期癌相似。这些结果表明，黏膜内非息肉样生长癌的黏膜下浸润发生得更快。
