Shi Bao-Min, Wang Xiu-Yan, Mu Qing-Ling, Wu Tai-Huang, Yang Zhen, Zhang Li, Li Da-Peng
Department of General Surgery, Shandong Provincial Hospital, Jinan 250021, China.
Hepatobiliary Pancreat Dis Int. 2002 Aug;1(3):388-91.
To investigate the significance of vascular endothelial growth factor (VEGF) in the pathogenesis of liver cirrhosis and the correlation between VEGF and proto-oncogene c-fos and c-myc in cirrhotic liver.
The proteins of VEGF, c-fos, and c-myc were identified immunohistochemically in each tissue section of 53 cases of liver cirrhosis. The correlations between VEGF, c-fos and c-myc were analyzed. The levels of VEGF protein in different Child gradings were also compared.
The proteins of VEGF were more highly expressed in Child A and B patients than in Child C patients and controls. The expressions of both c-fos and c-myc were not statistically significant between VEGF positive and negative patients.
The protein level of VEGF can reflect the compensation status of cirrhosis patients and may act as an anti-cirrhotic factor. The proto-oncogene c-fos, c-myc and VEGF may have different mechanisms in the course of cirrhosis or hepatic tumorigenesis.
探讨血管内皮生长因子（VEGF）在肝硬化发病机制中的意义以及VEGF与肝硬化肝脏中原癌基因c-fos和c-myc之间的相关性。
采用免疫组织化学方法对53例肝硬化患者的各组织切片进行VEGF、c-fos和c-myc蛋白鉴定。分析VEGF、c-fos和c-myc之间的相关性。同时比较不同Child分级中VEGF蛋白水平。
VEGF蛋白在Child A和B级患者中的表达高于Child C级患者及对照组。VEGF阳性和阴性患者之间c-fos和c-myc的表达无统计学差异。
VEGF蛋白水平可反映肝硬化患者的代偿状态，可能作为一种抗肝硬化因子。原癌基因c-fos、c-myc和VEGF在肝硬化或肝脏肿瘤发生过程中可能具有不同机制。
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