Verschoor Admar, Brockman Mark A, Gadjeva Mihaela, Knipe David M, Carroll Michael C
Center for Blood Research, Boston, MA 02115. Pathology, Pediatrics, and Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Immunol. 2003 Nov 15;171(10):5363-71. doi: 10.4049/jimmunol.171.10.5363.
The complement system, in addition to its role in innate immunity, is an important regulator of the B cell response. Complement exists predominantly in the circulation and although the primary source is hepatic, multiple additional cellular sources have been described that can contribute substantially to the complement pool. To date, however, complement produced by these secondary sources has been deemed redundant to that secreted by the liver. In contrast, using a bone marrow chimeric model, we observed that C3 synthesis by myeloid cells, a relatively minor source of complement, provided a critical function during the induction of humoral responses to peripheral HSV infection. Anti-viral Ab, as generated in an efficient humoral response, has been associated with protection from severe consequences of HSV dissemination. This report offers insight into the generation of the adaptive immune response in the periphery and describes a unique role for a nonhepatic complement source.
补体系统除了在固有免疫中发挥作用外，还是B细胞反应的重要调节因子。补体主要存在于循环系统中，虽然其主要来源是肝脏，但也有多种其他细胞来源被描述，这些来源可对补体库有显著贡献。然而，迄今为止，这些次要来源产生的补体被认为对肝脏分泌的补体是多余的。相比之下，我们使用骨髓嵌合模型观察到，髓样细胞合成的C3（补体的一个相对次要来源）在诱导对外周单纯疱疹病毒（HSV）感染的体液反应过程中发挥了关键作用。在有效的体液反应中产生的抗病毒抗体与预防HSV传播的严重后果相关。本报告深入探讨了外周适应性免疫反应的产生，并描述了非肝脏补体来源的独特作用。
