裸鼠瘤型麻风足垫的电子显微镜外观[已修正]

Electron microscope appearance of lepromatous footpads of nude mice [corrected].

作者信息

Job Charles K, McCormick Grgory T, Scollard David M, Truman Richard W

机构信息

Pathology Research Department, National Hansen's Disease Programs, L.S.U.-S.V.M., Skip Bertman Drive, Baton Rouge, Louisiana, USA.

出版信息

Int J Lepr Other Mycobact Dis. 2003 Sep;71(3):231-9. doi: 10.1489/1544-581x(2003)71<231:emaolf>2.0.co;2.

DOI:10.1489/1544-581x(2003)71<231:emaolf>2.0.co;2

PMID:14608819

Abstract

Footpad lesions of 3 nude mice infected by Mycobacterium leprae were studied at 9, 12, and 14 months after inoculation with light and electron microscope. The lesions were somewhat similar to those found in nodules in polar lepromatous leprosy. Striated muscles rather than nerves were the preferred site of the growth of M. leprae. Yet, M. leprae were identified in Schwann cells and endothelial cells, singly and in clumps. M. leprae filled macrophages, and free M. leprae were found in large numbers in the endoneurium without producing any significant demyelination.

摘要

对接种麻风分枝杆菌感染的3只裸鼠的足垫病变，在接种后9个月、12个月和14个月时用光镜和电镜进行了研究。这些病变与在极型瘤型麻风结节中发现的病变有些相似。横纹肌而非神经是麻风分枝杆菌生长的首选部位。然而，在施万细胞和内皮细胞中单独或成群地发现了麻风分枝杆菌。麻风分枝杆菌充满巨噬细胞，并且在神经内膜中发现大量游离的麻风分枝杆菌，未产生任何明显的脱髓鞘现象。