Gautam Sakshi, Sharma Devesh, Goel Anjana, Patil Shripad A, Bisht Deepa
Department of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282004, India.
Department of Biotechnology, GLA University, NH-2, Mathura-Delhi Road, Mathura 281406, India.
Proteomes. 2021 Jan 29;9(1):7. doi: 10.3390/proteomes9010007.
Although leprosy is curable, the identification of biomarkers for the early diagnosis of leprosy would play a pivotal role in reducing transmission and the overall prevalence of the disease. Leprosy-specific biomarkers for diagnosis, particularly for the paucibacillary disease, are not well defined. Therefore, the identification of new biomarkers for leprosy is one of the prime themes of leprosy research. Studying , the causative agent of leprosy, at the proteomic level may facilitate the identification, quantification, and characterization of proteins that could be potential diagnostics or targets for drugs and can help in better understanding the pathogenesis. This review aims to shed light on the knowledge gained to understand leprosy or its pathogen employing proteomics and its role in diagnosis.
尽管麻风病是可治愈的，但麻风病早期诊断生物标志物的识别对于减少疾病传播和总体流行率将起到关键作用。用于诊断的麻风病特异性生物标志物，尤其是针对少菌型麻风病的生物标志物，尚未得到明确界定。因此，识别麻风病新的生物标志物是麻风病研究的主要主题之一。在蛋白质组学水平上研究麻风病病原体麻风分枝杆菌，可能有助于识别、定量和表征那些有可能成为潜在诊断标志物或药物靶点的蛋白质，并有助于更好地理解发病机制。本综述旨在阐明利用蛋白质组学在了解麻风病或其病原体方面所获得的知识及其在诊断中的作用。
