Reaven Peter D, Thurmond Dewayne, Domb Alisa, Gerkin Richard, Budoff Matthew J, Goldman Steven
Division of Endocrinology and Metabolism, Department of Medicine, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, Arizona 85012, USA.
Am J Cardiol. 2003 Nov 15;92(10):1198-200. doi: 10.1016/j.amjcard.2003.07.030.
We recently demonstrated in subjects referred for the evaluation of cardiovascular disease that coronary atherosclerosis and coronary artery calcium (CAC) were reduced in Hispanics compared with non-Hispanic whites (NHWs). We now evaluate whether this ethnic disparity is present in a unselected healthy cohort of men. Despite the apparently worse risk factor profile, mean and median levels of CAC trended lower in Hispanic men, and the distribution of CAC scores differed from that of NHW (p <0.05), with fewer Hispanic subjects having CAC scores that are generally equated with extensive atherosclerotic burden (>400). These results demonstrate that healthy Hispanic men have reduced CAC compared with age-matched NHW men and this occurs despite evidence for a worse cardiovascular risk profile.
我们最近在因心血管疾病评估而转诊的受试者中发现，与非西班牙裔白人（NHW）相比，西班牙裔人群的冠状动脉粥样硬化和冠状动脉钙化（CAC）程度较轻。我们现在评估这种种族差异在未经选择的健康男性队列中是否存在。尽管西班牙裔男性的危险因素状况明显较差，但其CAC的平均水平和中位数水平呈下降趋势，且CAC评分分布与NHW不同（p<0.05），西班牙裔受试者中CAC评分通常等同于广泛动脉粥样硬化负担（>400）的人数较少。这些结果表明，与年龄匹配的NHW男性相比，健康的西班牙裔男性CAC较低，尽管有证据表明其心血管风险状况较差，但仍出现这种情况。
