关于成孔树枝状大分子桶板结构的存在及其形成机制的动力学证据。
Kinetic evidence for the existence and mechanism of formation of a barrel stave structure from pore-forming dendrimers.
作者信息
Zhang Jianbing, Jing Bingwen, Regen Steven L
机构信息
Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.
出版信息
J Am Chem Soc. 2003 Nov 19;125(46):13984-7. doi: 10.1021/ja036390h.
PMID:14611234
Abstract
A dendritic approach to the construction of a homologous series of pore-forming amphiphiles has been developed, based on the use of spermidine, spermine, lysine, and cholic acid. A kinetic analysis of Na+ transport across bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine by three dendritic amphiphiles has provided the strongest evidence to date for a barrel stave structure.
摘要
基于亚精胺、精胺、赖氨酸和胆酸的使用，已经开发出一种构建成孔两亲物同系物的树枝状方法。通过三种树枝状两亲物对Na⁺跨1-棕榈酰-2-油酰-sn-甘油-3-磷酸胆碱双层膜转运的动力学分析，为桶板结构提供了迄今为止最有力的证据。
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