通过建模和实验扩展对大肠杆菌代谢的认识。
Extending knowledge of Escherichia coli metabolism by modeling and experiment.
作者信息
Voit Eberhard O, Riley Monica
机构信息
Marine Biological Laboratory, Woods Hole, MA 02543, USA.
出版信息
Genome Biol. 2003;4(11):235. doi: 10.1186/gb-2003-4-11-235. Epub 2003 Oct 28.
Abstract
One of the challenges for 'post-genomic' biology is the integration of data from many different sources. Two recent studies independently take steps towards this goal for Escherichia coli, using mathematical modeling and a combination of gene expression and protein levels to predict new gene functions and metabolic behaviors.
摘要
“后基因组”生物学面临的挑战之一是整合来自许多不同来源的数据。最近的两项研究独立地朝着这个目标迈进，针对大肠杆菌，利用数学建模以及基因表达和蛋白质水平的组合来预测新的基因功能和代谢行为。
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Genome Biol. 2003;4(9):R54. doi: 10.1186/gb-2003-4-9-r54. Epub 2003 Aug 28.
2
Physiological studies of Escherichia coli strain MG1655: growth defects and apparent cross-regulation of gene expression.大肠杆菌菌株MG1655的生理学研究：生长缺陷及基因表达的明显交叉调控
J Bacteriol. 2003 Sep;185(18):5611-26. doi: 10.1128/JB.185.18.5611-5626.2003.
3
Toward a protein profile of Escherichia coli: comparison to its transcription profile.迈向大肠杆菌的蛋白质谱：与转录谱的比较。
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9232-7. doi: 10.1073/pnas.1533294100. Epub 2003 Jul 23.
4
Metabolic pathways in the post-genome era.后基因组时代的代谢途径。
Trends Biochem Sci. 2003 May;28(5):250-8. doi: 10.1016/S0968-0004(03)00064-1.
5
Thirteen years of building constraint-based in silico models of Escherichia coli.十三年来构建基于约束的大肠杆菌计算机模型。
J Bacteriol. 2003 May;185(9):2692-9. doi: 10.1128/JB.185.9.2692-2699.2003.
6
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Nat Biotechnol. 2001 Feb;19(2):125-30. doi: 10.1038/84379.
7
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Bioinformatics. 2000 Nov;16(11):1023-37. doi: 10.1093/bioinformatics/16.11.1023.
8
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