A2E，视觉循环的一种副产品。
A2E, a byproduct of the visual cycle.
作者信息
Sparrow Janet R, Fishkin Nathan, Zhou Jilin, Cai Bolin, Jang Young P, Krane Sonja, Itagaki Yasuhiro, Nakanishi Koji
机构信息
Department of Ophthalmology, Columbia University, 630 W. 168th Street, New York, NY 10032, USA.
出版信息
Vision Res. 2003 Dec;43(28):2983-90. doi: 10.1016/s0042-6989(03)00475-9.
A substantial portion of the lipofuscin that accumulates with age and in some retinal disorders in retinal pigment epithelial (RPE) cells, forms as a consequence of light-related vitamin A recycling. Major constituents of RPE lipofuscin are the di-retinal conjugate A2E and its photoisomers. That the accretion of A2E has consequences for the cell, with the adverse effects of A2E being attributable to its amphiphilic structure and its photoreactivity, is consistent with evidence of an association between atrophic age-related macular degeneration (AMD) and excessive lipofuscin accumulation.
随着年龄增长以及在某些视网膜疾病中，视网膜色素上皮（RPE）细胞中积累的大量脂褐素是与光相关的维生素A循环的结果。RPE脂褐素的主要成分是二视黄醛共轭物A2E及其光异构体。A2E的积累对细胞有影响，A2E的不良影响归因于其两亲结构和光反应性，这与萎缩性年龄相关性黄斑变性（AMD）与脂褐素过度积累之间存在关联的证据一致。
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