Koechlin Etienne, Ody Chrystèle, Kouneiher Frédérique
Institut National de la Santé et de Recherche Médicale, Université Pierre et Marie Curie, 9, quai St Bernard, 75005 Paris, France.
Science. 2003 Nov 14;302(5648):1181-5. doi: 10.1126/science.1088545.
The prefrontal cortex (PFC) subserves cognitive control: the ability to coordinate thoughts or actions in relation with internal goals. Its functional architecture, however, remains poorly understood. Using brain imaging in humans, we showed that the lateral PFC is organized as a cascade of executive processes from premotor to anterior PFC regions that control behavior according to stimuli, the present perceptual context, and the temporal episode in which stimuli occur, respectively. The results support an unified modular model of cognitive control that describes the overall functional organization of the human lateral PFC and has basic methodological and theoretical implications.
前额叶皮层（PFC）负责认知控制：即根据内部目标协调思想或行动的能力。然而，其功能结构仍知之甚少。通过对人类进行脑成像，我们发现外侧前额叶皮层是按照一系列执行过程组织起来的，这些过程从前运动区到前额叶前部区域，分别根据刺激、当前的感知情境以及刺激发生的时间片段来控制行为。这些结果支持了一种认知控制的统一模块化模型，该模型描述了人类外侧前额叶皮层的整体功能组织，并具有基本的方法学和理论意义。
