Lew Daniel J, Burke Daniel J
Department of Pharmacology and Cancer Biology, Box 3813, Duke University Medical Center, Durham, North Carolina 27710, USA.
Annu Rev Genet. 2003;37:251-82. doi: 10.1146/annurev.genet.37.042203.120656.
The mitotic spindle segregates chromosomes to opposite ends of the cell in preparation for cell division. Chromosome attachment to the spindle is monitored by the spindle assembly checkpoint, and at least in yeast cells, penetration of one spindle pole into the bud is monitored by the spindle position checkpoint. We review the historical origins of these checkpoints and recent progress in understanding their surveillance pathways. We also highlight fascinating but as yet unresolved questions, and examine crosstalk between the checkpoints.
有丝分裂纺锤体将染色体分离到细胞的相对两端，为细胞分裂做准备。纺锤体组装检查点监测染色体与纺锤体的附着情况，并且至少在酵母细胞中，纺锤体位置检查点监测一个纺锤极进入芽体的情况。我们回顾了这些检查点的历史起源以及在理解其监测途径方面的最新进展。我们还强调了一些引人入胜但尚未解决的问题，并探讨了检查点之间的相互作用。
