Sumbatyan N V, Korshunova G A, Bogdanov A A
Faculty of Chemistry, Lomonosov Moscow State University, Moscow, 119992, Russia.
Biochemistry (Mosc). 2003 Oct;68(10):1156-8. doi: 10.1023/a:1026318914546.
Biologically active peptide derivatives of 16-member macrolide antibiotics were synthesized as potential probes for the investigation of nascent peptide chain topography in the ribosomal exit tunnel. The tylosin and desmycosin aldehyde groups at the C6 position of the lactone ring were modified by the aminooxyacetyl-L-alanyl-L-alanine methyl ester.
合成了16元大环内酯类抗生素的生物活性肽衍生物，作为研究核糖体出口通道中新生肽链拓扑结构的潜在探针。内酯环C6位的泰乐菌素和去甲基泰乐菌素醛基用氨氧基乙酰-L-丙氨酰-L-丙氨酸甲酯进行修饰。
