Choi I S, Koh Y I
Department of Internal Medicine, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju, Korea.
Allergy. 2003 Nov;58(11):1114-6. doi: 10.1034/j.1398-9995.2003.00246.x.
In a study conducted 1 year ago, we found that Th1 immune enhancement following Bacille Calmette-Guérin (BCG) vaccination effectively suppressed human asthma. To investigate whether revaccination would further improve lung function, BCG vaccine was given again. Current lung function tended to improve in the Repeated BCG group (n = 9), but not in the Single BCG group (previously the placebo group) (n = 11), compared with that 1 year ago. The BCG vaccination improved lung function in both groups, and the Repeated BCG group showed a significant increase in the peripheral blood interferon gamma/interleukin 4 ratio. These findings suggest that repeated BCG vaccinations might be effective in asthma therapy.
在一年前进行的一项研究中，我们发现卡介苗（BCG）接种后Th1免疫增强可有效抑制人类哮喘。为了研究再次接种是否会进一步改善肺功能，再次接种了BCG疫苗。与一年前相比，重复接种BCG组（n = 9）的当前肺功能有改善趋势，但单次接种BCG组（先前的安慰剂组）（n = 11）则没有。BCG接种使两组的肺功能均得到改善，重复接种BCG组外周血干扰素γ/白细胞介素4比值显著升高。这些发现表明，重复接种BCG可能对哮喘治疗有效。
