Prince H Miles, McCormack Christopher, Ryan Gail, O'Keefe Rod, Seymour John F, Baker Chris
Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Australas J Dermatol. 2003 Nov;44(4):227-40; quiz 241-2. doi: 10.1046/j.1440-0960.2003..x.
Cutaneous lymphomas are rare and, although some are a manifestation of systemic lymphoma, the majority arise primarily from the skin. These primary cutaneous lymphomas comprise both T- and B-cell subtypes and represent a wide spectrum of disorders, which at times can be difficult to diagnose and classify. Classical therapeutic strategies include topical corticosteroids, phototherapy, radiotherapy, retinoids, extracorporeal photopheresis, topical chemotherapy, systemic chemotherapy and biological response modifiers. Newer therapies include the synthetic retinoid bexarotene, the immunotoxin conjugate denileukin diftitox, interleukin-12 and monoclonal antibodies such as alemtuzumab and rituximab.
皮肤淋巴瘤较为罕见，虽然有些是全身性淋巴瘤的一种表现，但大多数主要起源于皮肤。这些原发性皮肤淋巴瘤包括T细胞和B细胞亚型，代表了一系列广泛的疾病，有时难以诊断和分类。传统的治疗策略包括外用皮质类固醇、光疗、放疗、维甲酸、体外光化学疗法、局部化疗、全身化疗和生物反应调节剂。新的疗法包括合成维甲酸贝沙罗汀、免疫毒素偶联物地尼白介素-毒素融合蛋白、白细胞介素-12以及单克隆抗体，如阿仑单抗和利妥昔单抗。
