一种哺乳动物丝裂原活化蛋白激酶激酶的氨基酸序列。
The amino acid sequence of a mammalian MAP kinase kinase.
作者信息
Ashworth A, Nakielny S, Cohen P, Marshall C
机构信息
Chester Beatty Laboratories, Institute of Cancer Research London.
出版信息
Oncogene. 1992 Dec;7(12):2555-6.
PMID:1461659
Abstract
The amino acid sequence of the dual specificity mitogen-activated protein kinase kinase (MAPKK) has been determined by cDNA cloning and amino acid sequencing. MAPKK (393 residues, Mr 43,330) is a new member of the protein kinase subclass that comprises byr1 and STE7 that are involved in pheromone dependent signal transduction in yeast, wis1 a mitotic regulator in S. pombe and PBS2, which confers antibiotic resistance in S. cerevisiae.
摘要
通过cDNA克隆和氨基酸测序确定了双特异性丝裂原活化蛋白激酶激酶（MAPKK）的氨基酸序列。MAPKK（393个残基，分子量43,330）是蛋白激酶亚类的一个新成员，该亚类包括参与酵母中信息素依赖性信号转导的byr1和STE7、粟酒裂殖酵母中的有丝分裂调节因子wis1以及酿酒酵母中赋予抗生素抗性的PBS2。
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