Zijlstra Josée M, Hoekstra Otto S, Raijmakers Pieter G H M, Comans Emile F I, van der Hoeven Jacobus J M, Teule Gerrit J J, Jonkhoff A Roelof, v Tinteren Harm, Lammertsma Adriaan A, Huijgens Peter C
Department of Hematology Clinical PET Center, VU University Medical Center, Hospital Amstelveen, Amsterdam, The Netherlands.
Br J Haematol. 2003 Nov;123(3):454-62. doi: 10.1046/j.1365-2141.2003.04617.x.
A prospective study was performed, comparing gallium scintigraphy (67Ga) and positron emission tomography (PET) using fluorine-18 fluorodeoxyglucose (18FDG), to monitor the response of aggressive non-Hodgkin's lymphoma during treatment. 67Ga and 18FDG scans were performed in 26 patients after two cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) therapy. The scans were reviewed independently by four experienced nuclear physicians, who were blinded for the alternative scan technique and follow-up. Eleven out of 26 patients remained free from progression with a mean follow up of 25 +/- 5 months, whereas 14 patients relapsed, and one died of lung cancer. Interobserver variation was significantly greater for 67Ga than for 18FDG PET. Some 64% of patients who had a negative early restaging 18FDG PET remained free from progression versus 50% of patients with negative 67Ga scans. Only 25% of patients with a positive PET remained disease free versus 42% of 67Ga-positive patients. Time to progression was associated with 18FDG PET results, but not with those by 67Ga. 18FDG PET had better test characteristics than 67Ga for the evaluation of early response in aggressive non-Hodgkin's lymphoma patients.
进行了一项前瞻性研究，比较了镓闪烁扫描（67Ga）和使用氟-18氟脱氧葡萄糖（18FDG）的正电子发射断层扫描（PET），以监测侵袭性非霍奇金淋巴瘤在治疗期间的反应。在26例患者接受两个周期的CHOP（环磷酰胺、阿霉素、长春新碱、泼尼松）治疗后，进行了67Ga和18FDG扫描。由四位经验丰富的核医学医师独立审查扫描结果，他们对替代扫描技术和随访情况不知情。26例患者中有11例病情无进展，平均随访25±5个月，而14例患者复发，1例死于肺癌。67Ga的观察者间差异显著大于18FDG PET。早期重新分期18FDG PET结果为阴性的患者中约64%病情无进展，而67Ga扫描结果为阴性的患者中这一比例为50%。PET结果为阳性的患者中只有25%无病生存，而67Ga结果为阳性的患者中这一比例为42%。疾病进展时间与18FDG PET结果相关，但与67Ga结果无关。在评估侵袭性非霍奇金淋巴瘤患者的早期反应方面，18FDG PET比67Ga具有更好的检测特征。
