血清素的发育作用：来自小鼠分子遗传学的新消息。

The developmental role of serotonin: news from mouse molecular genetics.

作者信息

Gaspar Patricia, Cases Olivier, Maroteaux Luc

机构信息

INSERM U 106, Hôpital Salpêtrière, 47, Boulevard de l'Hôpital, 75651, Paris cedex 13, France.

出版信息

Nat Rev Neurosci. 2003 Dec;4(12):1002-12. doi: 10.1038/nrn1256.

DOI:10.1038/nrn1256

PMID:14618156

Abstract

New genetic models that target the serotonin system show that transient alterations in serotonin homeostasis cause permanent changes to adult behaviour and modify the fine wiring of brain connections. These findings have revived a long-standing interest in the developmental role of serotonin. Molecular genetic approaches are now showing us that different serotonin receptors, acting at different developmental stages, modulate different developmental processes such as neurogenesis, apoptosis, axon branching and dendritogenesis. Our understanding of the specification of the serotonergic phenotype is improving. In addition, studies have revealed that serotonergic traits are dissociable, as there are populations of neurons that contain serotonin but do not synthesize it.

摘要

针对血清素系统的新遗传模型表明，血清素稳态的短暂改变会导致成年行为的永久性变化，并改变大脑连接的精细线路。这些发现重新唤起了人们对血清素发育作用的长期兴趣。分子遗传学方法现在向我们表明，不同的血清素受体在不同的发育阶段发挥作用，调节不同的发育过程，如神经发生、细胞凋亡、轴突分支和树突形成。我们对血清素能表型的特异性的理解正在提高。此外，研究表明血清素能特征是可分离的，因为存在一些含有血清素但不合成血清素的神经元群体。