Palmer Alan M
Pharmidex, 72 New Bond Street, Mayfair, London, W1S 1RR, UK.
Curr Opin Investig Drugs. 2003 Jul;4(7):820-5.
Cholinomimetic drugs are now available to treat the cognitive impairments associated with Alzheimer's disease (AD), although evidence indicates that the effects of acetylcholinesterase (AChE) inhibitors on measures of cognitive function may be secondary to an action on attentional mechanisms. There is also convincing evidence suggesting that cholinomimetic drugs (e.g., AChE inhibitors and agents acting on cholinergic receptors) will have utility in the treatment of other, non-cognitive changes in behavior that are often associated with AD. This review describes some of the approaches to cholinergic therapy and considers the symptoms that are best suited to these treatment modalities.
目前已有拟胆碱药物可用于治疗与阿尔茨海默病（AD）相关的认知障碍，尽管有证据表明乙酰胆碱酯酶（AChE）抑制剂对认知功能指标的影响可能继发于其对注意力机制的作用。也有确凿证据表明，拟胆碱药物（如AChE抑制剂和作用于胆碱能受体的药物）在治疗其他通常与AD相关的非认知行为变化方面将具有效用。本综述描述了一些胆碱能治疗方法，并考虑了最适合这些治疗方式的症状。
