Mao Qing, Liu Jiagang, Liu Yanhui
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Oct;34(4):756-8.
Ganglioglioma is a lesion rarely encountered in the suprasellar region. Here we present a case of suprasellar region ganglioglioma that was totally removed by surgery. The patient was a 15-year-old female who complained of seizure for about 1 year, polyuria and eyesight descent for about 6 months. The neurological examination was without positive findings except bi-papilledema. By MRI, a huge cystic mass lesion was found in the suprasellar region, which caused slight obstructive hydrocephalus. The size of the mass was determined to be 4 cm x 3 cm x 3 cm. The levels of GH, PRL, ACTH, TSH, LH, FSH, TT3, TT4, CORT-1 were normal. We resected this lesion totally by trans-anterior portion of the foramen of right lateral ventricle. The postoperative paraffin section and immunohistochemistry showed ganglioglioma, GFAP(+), CK(-), NF(+). The follow-up time was 10 months; the patient was in good condition and enjoyed high quality of survival. This tumor has special embryological origins, clinical manifestations, and pathological features. Ganglioglioma of the suprasellar region will be of relatively favorable prognosis if it is diagnosed and resected in the early stage.
节细胞胶质瘤是一种罕见于鞍上区域的病变。在此，我们报告一例鞍上区域节细胞胶质瘤，该病例通过手术实现了全切。患者为一名15岁女性，主诉癫痫发作约1年，多尿及视力下降约6个月。神经系统检查除双侧视乳头水肿外无阳性发现。通过磁共振成像（MRI），在鞍上区域发现一个巨大的囊性肿块病变，导致轻度梗阻性脑积水。肿块大小确定为4 cm×3 cm×3 cm。生长激素（GH）、催乳素（PRL）、促肾上腺皮质激素（ACTH）、促甲状腺激素（TSH）、黄体生成素（LH）、卵泡刺激素（FSH）、总三碘甲状腺原氨酸（TT3）、总甲状腺素（TT4）、皮质醇-1（CORT-1）水平均正常。我们通过经右侧脑室前角将该病变全切。术后石蜡切片及免疫组化显示为节细胞胶质瘤，胶质纤维酸性蛋白（GFAP）（+）、细胞角蛋白（CK）（-）、神经丝蛋白（NF）（+）。随访时间为10个月；患者状况良好，生存质量高。该肿瘤具有特殊的胚胎学起源、临床表现及病理特征。鞍上区域节细胞胶质瘤若早期诊断并切除，预后相对良好。
