Yamaoka Kaoru, Kameyama Masaki
Department of Physiology, School of Medicine, Hiroshima University, Minami-Ku, Hiroshima, Japan.
Mol Cell Biochem. 2003 Nov;253(1-2):3-13. doi: 10.1023/a:1026036931170.
Regulation of L-type Ca2+ channels is complex, because many factors, such as phosphorylation, divalent cations, and proteins, specified or unspecified, have been shown to affect the channel activities. An additional complication is that these factors interact with one another to achieve final outcomes. Recent molecular technologies have helped to shed light on the mechanisms governing the activity of L-type Ca2+ channels. In this review article, three major topics concerning regulation of L-type Ca2+ channels in the heart are discussed, i.e. c-AMP dependent channel phosphorylation, role of magnesium (Mg2+), and the phenomenon of channel run-down.
L型钙通道的调节很复杂，因为许多因素，如磷酸化、二价阳离子和已明确或未明确的蛋白质，均已被证明会影响通道活性。另一个复杂情况是这些因素相互作用以实现最终结果。最近的分子技术有助于阐明控制L型钙通道活性的机制。在这篇综述文章中，讨论了有关心脏中L型钙通道调节的三个主要主题，即c-AMP依赖性通道磷酸化、镁（Mg2+）的作用以及通道耗竭现象。
