Rao Satish P Ramachandra, Surolia Avadhesha, Surolia Namita
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
Mol Cell Biochem. 2003 Nov;253(1-2):55-63. doi: 10.1023/a:1026049217966.
In order that malaria be successfully contained, it is important that one has a clear understanding of the normal physiology and biochemistry of the parasite essential to its survival in its human host. Until very recently, the conventional approaches to antimalarial chemotherapy have consistently been plagued with the uncanny ability of the parasite to evolve resistance to drugs. The recently discovered plasmodial fatty acid biosynthetic pathway as well as its inhibition by triclosan that classifies it as belonging to type II, provide with a very crucial breakthrough to the crusade against malaria. How triclosan could tilt the balance in favor of the human hosts of the malarial parasite in a malarial condition is discussed.
为了成功控制疟疾，重要的是要清楚了解疟原虫在人类宿主中生存所必需的正常生理和生物化学过程。直到最近，传统的抗疟化疗方法一直受到疟原虫对药物产生耐药性这一不可思议能力的困扰。最近发现的疟原虫脂肪酸生物合成途径及其被三氯生抑制（这使其属于II型），为抗击疟疾的斗争提供了一个非常关键的突破。本文讨论了在疟疾情况下三氯生如何能够使天平向疟原虫的人类宿主倾斜。
