Govind Anitha P, Thampan Raghava Varman
Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.
Mol Cell Biochem. 2003 Nov;253(1-2):233-40. doi: 10.1023/a:1026068017309.
The female sex steroid, estradiol 17beta, mediates its effect through its association with estrogen receptor present in the target cell. So far the major emphasis has been given to the genomic actions of the hormone mediated by the nuclear estrogen receptors. Recent years have seen a shift in the ideas revealing the existence of estradiol binding entities both in the plasma membrane and the endoplasmic reticulum. Though the true identity of this membrane associated receptors is far from being known, a functional role for the same have been implicated both at the genomic as well as the non-genomic level. The major focus of the review is to highlight the existence of membrane associated estrogen receptors and receptor-related proteins and the functional roles played by some of them. The signalling events exerted by this class of membrane associated estrogen receptor could partly explain the physiological significance of estrogen in cardiovascular disease, osteoporosis and breast cancer as well as the molecular mechanism associated with xenoestrogen action.
雌性甾体激素17β-雌二醇通过与靶细胞中存在的雌激素受体结合来介导其作用。到目前为止，主要的研究重点一直是由核雌激素受体介导的该激素的基因组作用。近年来，观念上发生了转变，揭示了在质膜和内质网中均存在雌二醇结合实体。尽管这种膜相关受体的真实身份远未明确，但已暗示其在基因组水平和非基因组水平均具有功能作用。本综述的主要重点是强调膜相关雌激素受体和受体相关蛋白的存在，以及其中一些蛋白所发挥的功能作用。这类膜相关雌激素受体所引发的信号事件可以部分解释雌激素在心血管疾病、骨质疏松症和乳腺癌中的生理意义，以及与外源性雌激素作用相关的分子机制。
