Wreford-Brown C E, Hampson N B
Center for Hyperbaric Medicine, Virginia Mason Medical Center, Seattle, Washington, USA.
Undersea Hyperb Med. 2003 Fall;30(3):175-9.
To determine hyperbaric oxygen (HBO2) treatment practices for osteoradionecrosis (ORN) of the mandible in North America, we surveyed hyperbaric facilities listed in the 1998 UHMS Chamber Directory. A survey response rate of 99.7% was achieved. Among the 316 facilities listed, 280 treat or would treat mandibular ORN with HBO2. Twelve different hyperbaric treatment protocols for the condition were reported. Approximately three-quarters of facilities utilize a protocol administering 90 minutes of 100% oxygen breathing at a treatment pressure of 2.4-2.5 atmospheres absolute (atm abs). The remaining one-quarter of facilities apply alternate hyperbaric treatment protocols. In summary, mandibular ORN is commonly treated at North American hyperbaric facilities but there is a lack of uniformity with regard to the protocol utilized for hyperbaric oxygen administration. There are no clinical data to support that any one treatment protocol is superior in out come to any other.
为确定北美地区下颌骨放射性骨坏死（ORN）的高压氧（HBO₂）治疗方法，我们调查了1998年UHMS舱室名录中列出的高压氧治疗机构。调查回复率达到了99.7%。在列出的316家机构中，有280家治疗或愿意用HBO₂治疗下颌骨ORN。报告了针对该病症的12种不同的高压氧治疗方案。大约四分之三的机构采用在2.4 - 2.5绝对大气压（atm abs）的治疗压力下进行90分钟100%氧气呼吸的方案。其余四分之一的机构采用其他高压氧治疗方案。总之，北美地区的高压氧治疗机构普遍治疗下颌骨ORN，但在用于高压氧治疗的方案方面缺乏一致性。没有临床数据支持任何一种治疗方案在疗效上优于其他方案。
