Donos Nikolaos, Glavind Leif, Karring Thorkild, Sculean Anton
Department of Periodontology, Royal Dental College, University of Aarhus, Denmark.
Int J Periodontics Restorative Dent. 2003 Oct;23(5):507-12.
The aim of the present study was to evaluate the clinical outcome following application of an enamel matrix derivative in degree II mandibular furcation involvements. Ten patients with chronic periodontitis, presenting a total of eight buccal and eight lingual degree II furcation involvements, were included in the study. The following clinical parameters were evaluated prior to treatment and after 6, 12, and 36 months: probing attachment level in horizontal direction in the buccal and/or lingual furcation area (PAL-H) and probing attachment level in vertical direction (PAL-V) at the center of the buccal/lingual furcation area. The postoperative healing phase was uneventful in all cases, and no complications were observed throughout the entire study period. At 6 months, the mean PAL-H of the buccal defects was reduced from 4.0 +/- 1.3 mm to 2.6 +/- 1.4 mm, and the mean PAL-V was reduced from 5.2 +/- 2.0 mm to 4.0 +/- 1.6 mm. At the lingual defects, the mean PAL-H was reduced from 3.6 +/- 1.3 mm to 3.1 +/- 1.1 mm, and the mean PAL-V was reduced from 5.6 +/- 2.0 mm to 4.3 +/- 1.8 mm. At 12 and 36 months, clinical parameters remained similar, without any further clinical improvement. These results suggest that the treatment of degree II mandibular furcation involvements with enamel matrix derivative might lead to clinical improvement. However, controlled clinical trials and histologic studies are needed to examine the clinical significance of these results and the characteristics of healing following application of enamel matrix derivative.
本研究的目的是评估釉基质衍生物应用于下颌Ⅱ度根分叉病变后的临床疗效。本研究纳入了10例慢性牙周炎患者，共有8处颊侧和8处舌侧Ⅱ度根分叉病变。在治疗前以及治疗后6个月、12个月和36个月评估以下临床参数：颊侧和/或舌侧根分叉区域水平方向的探诊附着水平（PAL-H）以及颊侧/舌侧根分叉区域中心垂直方向的探诊附着水平（PAL-V）。所有病例术后愈合过程均顺利，在整个研究期间未观察到并发症。6个月时，颊侧缺损的平均PAL-H从4.0±1.3mm降至2.6±1.4mm，平均PAL-V从5.2±2.0mm降至4.0±1.6mm。舌侧缺损处，平均PAL-H从3.6±1.3mm降至3.1±1.1mm，平均PAL-V从5.6±2.0mm降至4.3±1.8mm。在12个月和36个月时，临床参数保持相似，没有进一步的临床改善。这些结果表明，用釉基质衍生物治疗下颌Ⅱ度根分叉病变可能会带来临床改善。然而，需要进行对照临床试验和组织学研究来检验这些结果的临床意义以及应用釉基质衍生物后的愈合特征。
