膜相关磷脂酶A2刺激两种小鼠成纤维细胞中的DNA合成。
Membrane-associated phospholipase A2 stimulates DNA synthesis in two murine fibroblasts.
作者信息
Kurizaki T, Egami H, Murata K, Kiyohara H, Okazaki S, Yoshida N, Ogawa M
机构信息
Department of Surgery II, Kumamoto University Medical School, Japan.
出版信息
Res Commun Chem Pathol Pharmacol. 1992 Oct;78(1):39-45.
The effect of human membrane-associated phospholipase A2 (M-PLA2) on DNA synthesis in fibroblasts was examined in order to clarify its biological function. Human M-PLA2 added exogenously to the fibroblast cell lines Swiss 3T3 and BALB/3T3 was found to augment their DNA synthesis. This stimulation of DNA synthesis was not affected by treatment with indomethacin. Our results suggest that human M-PLA2 itself has a mitogenic effect on fibroblasts independent of arachidonate products such as prostaglandins.
为阐明人膜相关磷脂酶A2（M-PLA2）的生物学功能，研究了其对成纤维细胞DNA合成的影响。将人M-PLA2外源添加到成纤维细胞系瑞士3T3和BALB/3T3中，发现可增强它们的DNA合成。这种对DNA合成的刺激不受吲哚美辛处理的影响。我们的结果表明，人M-PLA2本身对成纤维细胞具有促有丝分裂作用，且不依赖于花生四烯酸产物如前列腺素。
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